Evidence for the Extrathymic Origin of Intestinal TCR T Cells in Normal Rats and for an Impairment of This Differentiation Pathway in BB Rats
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INDUCTION OF TYPE 1 DIABETES IN DIABETES-RESISTA NT (BB-DR) RATS
The BioBreeding- Diabetes Prone (BB-DP) rat spontaneously develops an autoimmune diabetic syndrome that is dependent on the RT1 u Major Histocompatibility Complex (MHC) haplotype and homozygosity for an allele at the Lymphopenia (Lyp) locus. Lyp mutation is responsible for a peripheral T -lymphopenia. There are other genetic loci contributing to diabetes susceptibility in this strain. BB ra...
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تاریخ انتشار 2002